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Nandrolone Decanoate Wikipedia


Nandrolone Decanoate – Wikipedia

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Pharmacological properties [edit | edit code]

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Nandrolone (19-nor-4-androsten-3-one, 17β-ol or 4-estren-17β-ol-3-one) is an anabolic steroid with a mild androgenic effect. The action develops gradually (3 days after i / m administration), reaches a maximum on the 7th day after administration and lasts at least 3 weeks. Metabolized in the liver to form various forms of ketosteroids, approximately 90% of which are excreted in the urine.

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Indications [edit | edit code]

Chronic infectious diseases, severe trauma, extensive surgical interventions, steroid myopathy, anemia in chronic renal failure, myelofibrosis, myelosclerosis, myeloid aplasia of the bone marrow (refractory to conventional therapy), damage to the bone marrow by metastases of malignant neoplasms, myelotoxic drugs, and salt drugs; inoperable (metastatic) breast carcinoma in postmenopausal or after ovariectomy; growth retardation in children caused by growth hormone deficiency.

Contraindications [edit | edit code]

Hypersensitivity, carcinoma or hypertrophy of the prostate gland, malignant tumors of the breast in men, breast carcinoma in women with hypercalcemia (capable of activating osteoclasts and causing bone resorption), pregnancy (has embryotoxicity, fetotoxicity, can cause musculinization – female fetus X) in the USA [2], IHD, severe atherosclerosis; heart failure and other conditions accompanied by edema syndrome, acute and chronic liver diseases, incl. alcoholic lesions, nephritis, nephrotic syndrome, breastfeeding.

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Application [edit | edit code]

V / m, deep. Nandrolone decanoate: for anemia (along with iron preparations) – 100-200 mg (for women – 50-100 mg) once a week; to stimulate anabolic processes – 50-200 mg (women – 50-100 mg) 1 time in 1-4 weeks; children 2-13 years old – 25-50 mg 1 time in 2-3 weeks. The duration of the course (with a 1–4-week interval between injections) is up to 12 weeks, the second course is 8 weeks after the last injection of the drug. Treatment is carried out against the background of a diet rich in proteins. For breast carcinoma (nandrolone phenylpropionate) – 50-100 mg once a week; the duration of the course is individual.

Side effects [edit | edit code]

In men and women – the progression of atherosclerosis (an increase in the concentration of LDL and a decrease in the concentration of HDL), iron deficiency legal 5 ways to look proviron info as proviron 25mg anemia, peripheral edema, dyspeptic disorders (pain in the abdomen and epigastric region, nausea, vomiting), impaired liver function with jaundice, leukemia-like syndrome (changes in leukocytic formula, pain in long tubular bones), hypocoagulation with a tendency to bleeding, hepatonecrosis (dark stools, vomiting with blood, headache, discomfort, respiratory failure), hepatocellular carcinoma, hepatic purpura (dark urine, discoloration of or macular hemorrhagic rash on the skin and mucous membranes, pharyngitis or tonsillitis), cholestatic hepatitis (yellow staining of the sclera and skin, pain in the right hypochondrium, dark-colored urine, discolored stools). In women, virilism (enlargement of the clitoris, coarsening of the voice, dys- and amenorrhea, male-pattern hair growth), hypercalcemia (depression of the central nervous system, nausea, vomiting, fatigue). In men: in the prepubertal period – virilism (acne, enlarged penis, priapism, formation of secondary sexual characteristics), idiopathic hyperpigmentation of the skin, slowing or cessation of growth (calcification of the epiphyseal growth zones of tubular bones); in the postpubertal period – irritation of the bladder (increased frequency of urge), breast thickening, gynecomastia, priapism, in old age – hypertrophy and / or carcinoma of the prostate gland. Often, with prolonged use in men, it can cause the so-called ”Deca-Dick”, which is provoked by an increase in prolactin levels.

Directions [edit | edit code]

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Although the drug has practically no androgenic properties, nevertheless, women should be prescribed the pharmacom steroids drug after assessing the ratio of the risk of side effects and the potential benefit of therapy. Not recommended for children. Retabolil can be used as a means of adjuvant therapy in combination with corticosteroids, tuberculostatic and cytostatic drugs, as well as radiation therapy. It should be used with caution in diseases of the cardiovascular system, liver and kidneys, as well as epilepsy, migraine and glaucoma. During the treatment period, due to the risk of sodium and fluid retention in the body, intraocular pressure should be monitored.

During treatment, the indicators of liver function tests may change, so they should be monitored monthly.

Before and during the use of the drug, a rectal examination of the prostate gland should be performed.

In patients with a progressive malignant tumor, the duration of the course of treatment is determined individually, taking into account the results of the study of the buy protect your methandienone info with these functional parameters of the liver. For children, the drug is prescribed only after assessing the balance of benefits and risks from its use..

Interactions [edit | edit code]

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Glucocorticoids, mineralocorticoids, corticotropin, sodium-containing drugs and food rich in sodium potentiate (mutually) fluid retention in the body, increase the risk of developing edema, and increase the severity of acne. Enhances the effects of antiplatelet agents, indirect anticoagulants, insulin and oral antidiabetic agents (inhibits their biotransformation), weakens – STH and its derivatives (accelerates the mineralization of the epiphyseal growth zones of tubular bones). Reduces hepatotoxicity of other drugs.

Overdose [edit | edit code]

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In case of an overdose of nandrolone, side effects increase.

Storage conditions [edit | edit code]

Store in a dry, dark place at a temperature of 15-30 ° C. Keep out of the reach of children.

How dope [edit | edit code]

Nandrolone is more active than testosterone and therefore is of interest as a doping agent. In the body, nandrolone is produced from testosterone by oxidation of the methyl group and subsequent retro-Kleisen rearrangement.

Therefore, the International Olympic Committee has established the maximum concentration of Nandrolone in the urine of athletes, at 2 nanograms / ml for men and women..

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Notes [edit | edit code]

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